The proprietary blend in  has been developed to support:

• Normal Appetite
• Fat emulsification
• Fat loss
• Energy levels

All natural, non stimulant dietary supplement to support fat loss and normal apetitte.

All the statements above have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

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Adipostrin is comprised by the following uniquely combined key ingredients:

Hoodia Gordonii
This South African Cactus has been getting a lot of attention for its remarkable appetite suppressing properties. People using Hoodia Gordonii have reported appetite suppression as quickly as 20-30 minutes after intake. In combination with jojoba Seeds, 5HTP and L-phenylanalanine, it makes Adipostrin the most powerful natural appetite suppressant ever formulated.

L-Phenylalanine
Phenylalanine is an essential amino acid that acts as an appetite suppressant by administrating the release of an intestinal hormone—cholecystokinin—which signals the brain to feel satiated after eating. Here's how appetite control works: cholecystokinin (CCK) is released as food enters the stomach. It tells the digestion to slow down and then gives the message to the brain that you are 'full' … so your appetite naturally decreases. This takes time - usually around 20 minutes. Phenylalanine is found in a variety of foods, including almonds, avocados, bananas, brown rice, cheese, corn, eggs, fish, lima beans, peanuts, pumpkin seeds, sesame seeds and soy products. Problem is, you'd have to eat lots of extra calories in. If you take phenylalanine 30 minutes to one hour before eating a meal, you'll notice that you'll feel full faster — so you don't fill up on extra calories that you don't need! And not only that, you'll stay full longer so you don't get that late afternoon or after-dinner snack attack. Before you know it, those extra pounds you've been carrying around will start to melt away—safely and effortlessly.

CLA (Conjugated Linoleic Acid)
CLA is an interesting compound that has been shown in many recent studies to have profound fat loss effects in humans. This advanced form of an essential fatty acid can actually reduce body fat while dieting. Researchers have proposed several ways on how CLA works. One, it interferes with a substance in your body called lipoprotein lipase that helps store fat in your body and CLA also helps your body use its existing fat for energy. So you prevent fat storage while burning the fat you have. Effective doses range from 1.8 - 6 grams daily.

Carnitine (L-carnitine)
L-Carnitine is a vitamin like nutrient essential for energy production and fat metabolism. L-Carnitine helps transport long chain fatty acids across the mitochondrial membrane for subsequent fat breakdown and energy production. There is some research showing the benefits of L-carnitine as a weight loss agent. A special form of L carnitine (L-carnitine L-tartrate) has been shown in newer research to reduce muscle breakdown secondary to weight training. Taking 1-2 grams daily may be effective.

Pyruvate
This is a metabolic intermediary substance that has been shown to cause fat loss at higher doses. It can stimulate metabolic rate by supporting optimal thyroid hormone function in the liver. It seems to also increase fat utilization as well and lower the regaining of weight after a diet program. High doses like 10 grams and above daily seem to be best.

Simmondsin (jojoba oil)
Jojoba oil has been used for years in cosmetic preparations but this particular extract has special effects. This special herbal extract has potential for powerful appetite suppression effects. Deceased food intake can be a key to fat and weight loss and this ingredient has potential to be one of the most powerful appetite suppressors around. In fact, one of the main ways that ephedrine/caffeine combinations seem to boost weight/fat loss is through appetite suppression. In the 1990s, Belgian researcher Marnix Cokelaere discovered that simmondsin was acting as a hunger satiety ingredient. This allowed him to reinterpret earlier experiments with mice and cattle fed diets supplemented with jojoba meal. This ingredient satisfied the animals' hunger, causing the decline in feed intake. In fact, many animal studies show the powerful appetite suppression effects of this ingredient. Food intake was decreased significantly in many experiments with animals. In one study published in the British Journal of Nutrition, researchers verified a significant reduction in food intake in the simmondsin group of rats. This effect was even greater in obese rats. Simmondsin seems to work by allowing the body to stay full longer and thus control satiety. Simmondsin is thought to either directly stimulate CCK (Cholecystokinin), a hormone that helps control food intake and seems to slow gastric motility, release or bind to the same receptors as CCK.

Chromium
After scouring the research on chromium, the results are for the most part equivocal in terms of fat loss, strength, and muscle mass gain (some positive, some negative). I believe that the effects of chromium depend on several factors including dosage, timing, and type of chromium used. There is definitely an issue with chromium bioavailability, especially from food sources like brewers yeast, broccoli, and cinnamon. That is why supplementation with a bound form of chromium is best (this helps form stable chromium complexes). The two most popular forms of this trace mineral are chromium picolinate (bound to a metabolite of the amino acid tryptophan) and chromium polynicotinate (a special niacin bound chromium). Although the picolinate form has been used in more studies, the polynicotinate form seems to be better absorbed and safer (although both forms are quite safe). An animal study shows that the polynicotinate form is better absorbed and retained and a study published in Medicine & Science in Sports & Exercise in 1997 showed that niacin bound chromium caused significant weight loss in obese women when combined with exercise while chromium picolinate actually caused weight gain (not good!). There was a scare about chromium picolinate being damaging to chromosomes and having mutagenic effects but the studies that showed this were done in hamster ovary cells. Chromium is a trace mineral and the Estimated Safe and Adequate Daily Dietary Intake (ESADDI) is 50-200 mcg. Chromium is essential for normal protein, fat, and carbohydrate metabolism. Chromium is important for energy production, and also plays a key role in regulating appetite, reducing sugar cravings, and lowering body fat according to a few studies. Chromium helps insulin metabolize fat, turn protein into muscle, and convert sugar into energy. The primary function of chromium is to potentate the effects of insulin and thereby enhance glucose, amino acid and fat metabolism. Insulin is a key hormone produced by the pancreas that helps regulate blood sugar levels and can help control appetite and nutrient uptake into muscle cells. Chromium enhances insulin sensitivity by improving insulin binding, insulin receptor number, and insulin receptor enzymes.

What’s interesting is that one recent study published in the Alternative Medicine Review stated that “the beneficial effects of chromium on serum glucose and lipids and insulin resistance occur even in the healthy.” Exercise induces chromium losses in athletes and may lead to chromium deficiency resulting in impaired insulin function. Athletes may have an increased requirement for chromium. Signs of chromium deficiency include high blood glucose levels, increased cholesterol and triglycerides, and decreased HDL (“good” cholesterol) levels.

The biologically active component of glucose tolerance factor (GTF), which potentates insulin activity and is responsible for normal insulin function, is dependent on chromium. Chromium has been shown to ameliorate type II diabetes, reduce cholesterol levels, help decrease fat mass, and increase lean body mass, as well as reduce weight. These effects are in conjunction with chromium supplementation AND exercise of course. One study published in the Diabetes, Obesity and MetabolismJournal using 600 mcg of chromium (from polynicotinate) daily in overweight women showed significant weight loss and sparing of muscle mass over a two month period without any adverse effects.

Yet another study published in the Western Journal of Medicine concluded that “chromium picolinate is efficacious in lowering blood lipids in humans.”

A fairly recent study conducted at Georgetown University Medical Center and published in May 2002 showed that chromium polynicotinate can enhance insulin sensitivity and reduce age-related disorders including problems with glucose metabolism.

One thing to watch out for is taking chromium with iron as they both compete for absorption and binding to transferrin. Although not conclusive, it may be a good idea to take chromium and iron supplements separately. Based on the research and my own personal experience, I have found that one of the best times to take chromium is right after a weight training workout with a post workout shake to enhance nutrient absorption. According to most of the research, good dosages range from 400-1000 mcg of chromium in divided doses daily taken with meals (preferably from chromium polynicotinate).

(All the single ingredient literature above is courtesy of www.tsrf.com , an unbiased source of information and research for orthomolecular ingredients)

*This statement has not been evaluated by the Food and Drugs Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
ATTENTION:
A PROPER DIET AND EXERCISE ROUTINE MUST BE IMPLEMENTED WITH THE USE OF THIS PRODUCT FOR THE ACHIEVEMENT OF OPTIMAL RESULTS

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