A chance to redefine Sexual Chemistry…
is the first and only nutritional supplement designed to support ejaculation in men. Prematrol™ for Men may be helpful for:

• Sexual Anxiety
• Sexual Relaxation
• Sexual Satisfaction

Among the key ingredients in Prematrol's exclusive blend are:
Passiflora (Passion flower) Extract has traditionally been used for nervous restlessness and gastrointestinal spasms. In short, the effects of passion flower were believed to be primarily on the nervous system, particularly for anxiety due to mental worry and overwork. For many years, plant researchers believed that a group of harmane alkaloids were the active constituents in passion flower. Recent studies, however, have pointed to the flavonoids in passion flower as the primary constituents responsible for its relaxing and anti-anxiety effects. European pharmacopoeias typically recommend passion flower products primarily as an anti-anxiety treatment.

Griffonia Simplicifolia Seed Extract (5-Hydroxytryptophan or 5-HTP) is an extract of seeds from a natural plant found in costal West Africa. 5-HTP is the direct metabolic precursor of serotonin and is important for the production of melatonin. Serotonin is an important brain chemical involved in mood, behavior, appetite and sleep. 5-HTP is a natural supplement that converts in the brain into serotonin. This is done without monoamine oxidase inhibition (MAOI) and without the serious side effects of other antidepressant drugs such as Prozac and Zoloft, which belong to a class of drugs known as selective serotonin reuptake inhibitors (SSRIs). These drugs influence serotonin levels by blocking its inactivation, which increases serotonin levels indirectly, causing a cellular deficiency. Unlike the drugs listed above, serotonin from Griffon is not chemically held at receptor sites where it can accumulate and cause side effects. The excess is broken down and eliminated. Increasing serotonin levels with natural herbal products like Graffiti mimic the effects of SSRI's without adverse side effects. Important byproducts most commonly associated with SSRI's are delayed ejaculation and delayed orgasm. Sexual desire (libido) and arousal difficulties are sometimes reported, however, the specific association to SSRI use has not been consistently shown.
Important byproducts most commonly associated with SSRI's are delayed ejaculation and delayed orgasm. Sexual desire (libido) and arousal difficulties are sometimes reported, however, the specific association to SSRI use has not been consistently shown.
Cistanche Fruit Extract The Chinese drug "Rou Cong-rong" (Herba Cistanchis) is one of the commonly used drugs in Chinese traditional medicine, where it is used to reinforce the vital function of kidney, especially that of the sexual organs for the treatment of impotence, premature ejaculation in men, and also infertility.

Vitamin B6 consists of: Pyridoxine, Pyridoxal and Pyridoxamine, and their phosphate esters. The metabolically active coenzyme form of Vitamin B6 is Pyridoxal 5-Phosphate. Animal studies have shown that Vitamin B6 depletion leads to the development of hypertension, which is normalized within 24 hours by repletion with the vitamin. Vitamin B6 deficiency is reported in as many as 79 percent of people with depression (compared to only 29 percent of other people). It appears that a Vitamin B6 deficiency does not allow nerve cells to manufacture adequate amounts of serotonin and other chemicals critical to the proper functioning of the nervous system; this may result in insomnia, depression, irritability and nervousness. Vitamin B6 deficiency can disrupt formation of neurotransmitters. Vitamin B6 is a co-enzyme needed for conversion of tryptophan to serotonin and phenylalanine and tyrosine to norepinephrine. These neurotransmitters are integrally related to depression. Vitamin B6 supplementation often improves moods.

Folic Acid is a water-soluble vitamin belonging to the B-complex family. B vitamins work best together as a team which is why it is generally recommended that we take a B-complex supplement, rather than individual B vitamins. In a recently published double blind study 127 patients with major depression were treated with Prozac and either a placebo or 500 mcg per day of folic acid. There was a significantly greater improvement in the folic acid group than in the placebo group. Research further indicates that folic acid may contribute to better sperm count and quality and therefore may help men father healthier babies.

References:
Anti-anxiety studies on extracts of Passiflora incarnata Linneaus Dhawan K, Kumar S, Sharma A. J Ethnopharmacol. 2001 Dec;78(2-3):165-70
Passionflower in the treatment of generalized anxiety: a pilot double-blind randomized controlled trial with oxazepam. S. Akhondzadeh PhD12, H. R. Naghavi MD1, M. Vazirian MD1, A. Shayeganpour PharmD2, H. Rashidi PharmD2 & M. Khani MSc2. Journal of Clinical Pharmacy & Therapeutics Volume 26 Issue 5 Page 363 - October 2001 doi:10.1046/j.1365-2710.2001.00367.x
A double-blind, controlled trial in primary care patients with generalized anxiety: a comparison between buspirone and oxazepam. J Clin Psychiatry. 1990 Sep;51 Suppl:40-5.

PE article by Dr. M.J. Noble, click here.